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Establishment of iPS cells from amyotrophic lateral sclerosis model mice and motor neuronal differentiation

โœ Scribed by Kenichi Komatsu; Haruhisa Inoue; Takayuki Kondo; Shiho Kitaoka; Kazutoshi Takahashi; Shinya Yamanaka; Ryosuke Takahashi


Book ID
116779221
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
115 KB
Volume
71
Category
Article
ISSN
0168-0102

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โœ Giuseppina D'Alessandro; Eleonora Calcagno; Silvia Tartari; Milena Rizzardini; R ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 865 KB

Impairment of mitochondrial function might contribute to oxidative stress associated with neurodegeneration in amyotrophic lateral sclerosis (ALS). Glutamate levels in tissues of ALS patients are sometimes altered. In neurons, mitochondrial metabolism of exogenous glutamine is mainly responsible for