Lack of modulation of MDR1 gene expressi
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Amadeo M. Parissenti; Brian R. Gannon; David J. Villeneuve; Angela F. Kirwan-rhu
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Article
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1999
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John Wiley and Sons
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French
β 172 KB
π 2 views
The drug transporter P-glycoprotein (P-gp) appears to play an important role in the ability of tumor cells to evade killing by chemotherapeutic agents. Using pharmacological inhibitors of cAMP-dependent protein kinase (PKA), it has been suggested that, similar to rodent model systems, the human P-gp