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Establishment of an interleukin 6 (IL 6)/B cell stimulatory factor 2-dependent cell line and preparation of anti-IL 6 monoclonal antibodies

✍ Scribed by Tadashi Matsuda; Toshio Hirano And; Tadamitsu Kishimoto


Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
766 KB
Volume
18
Category
Article
ISSN
0014-2980

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Interleukin-6 (IL-6) belongs to a family of cytokines that use receptors consisting of a common signal-transducing chain (gp130). Baf/3 cells transfected with the human IL-6 receptor (IL-6R) and gp130 (Baf/3-gp130/IL-6R) can only grow in medium containing IL-6. We attempted to interrupt the signal t