Establishment of a mutant from human monocytic leukaemia U937 that exhibitsa genetically dominant resistance to TNFα-induced apoptosis

Genetically recessive mutant of human mo

Genetically recessive mutant of human monocytic leukemia U937 resistant to tumor necrosis factor-α-induced apoptosis

✍ Jian Dong; Mikihiko Naito; Tetsuo Mashima; Won Hee Jang; Takashi Tsuruo 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 205 KB

Tumor necrosis factor-a (TNF-a) is a cytokine that induces apoptosis in various cell systems by binding to the TNF receptor (TNFR). To study TNF-a-induced apoptosis, we isolated and characterized a novel TNF-a-resistant variant, U937/ TNF clone UA, from human monocytic leukemia U937 cells. The UA ce