✦ LIBER ✦

Establishment of a metastatic model of human hepatocellular carcinoma in nude mice via orthotopic implantation of histologically intact tissues

✍ Scribed by Fan X. Sun; Zhao Y. Tang; Kang D. Liu; Sheng L. Ye; Qiong Xue; Dong M. Gao; Zeng C. Ma

Publisher: John Wiley and Sons
Year: 1996
Tongue: French
Weight: 645 KB
Volume: 66
Category: Article
ISSN: 0020-7136
DOI: 10.1002/(sici)1097-0215(19960410)66:2<239::aid-ijc17>3.0.co;2-7

No coin nor oath required. For personal study only.

✦ Synopsis

A highly metastatic LCI-D2O model of human hepatocellular carcinoma (HCC) was obtained via orthotopic implantation of a histologically preserved metastatic tumour selected from I of 30 surgical specimens, and has been maintained for I8 passages in nude mice. All mice with transplanted turnours exhibited 100% transplantability and metastatic ability, as well as various manifestations reminiscent of tumour behaviour in HCC patients. These included: local growth, regional invasion, spontaneous metastasis to liver, lymph nodes and lungs, and peritoneal seeding. Histological characteristics of the LCI-D2O tumour were similar to those of the original turnour. Karyotypic analysis revealed heteroploid cells. lmmunohistochemically, expression of AFP and HBxAg was shown. Our nude mouse model with its high metastatic rate and short latency period could be an interesting tool for the study of human HCC.

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