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Essential tremor is not associated with α-synuclein gene haplotypes

✍ Scribed by Simona Pigullo; Emilio Di Maria; Roberta Marchese; Emilia Bellone; Rossella Gulli; Cesa Scaglione; Stella Battaglia; Paolo Barone; Paolo Martinelli; Giovanni Abbruzzese; Franco Ajmar; Paola Mandich

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
443 KB
Volume
18
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

A specific allele of the NACP‐Rep1 polymorphism within the α‐synuclein promoter was found to be associated both with Parkinson's disease and essential tremor. We repeated the association study on a large series of Italian patients with essential tremor using a panel of polymorphisms within the α‐synuclein gene. Our results did not confirm the association reported previously and failed to identify a α‐synuclein specific haplotype as susceptibility factor for essential tremor. © 2003 Movement Disorder Society

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