In polycythemia Vera (PV), treatment with chlorambucil and radioactive phosphorus (p32) increases the risk of leukemic transformation from 1% to 13-14%. This risk has been estimated to be 1-5.9% with hydroxyurea (HU) therapy. When compared with historical controls, the risk with use of HU does not a
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Essential thrombocythemia, polycythemia vera, and myelofibrosis: Current management and the prospect of targeted therapy
β Scribed by Ayalew Tefferi
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 117 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0361-8609
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## Abstract ## BACKGROUND: Advanced age and a history of thrombosis were wellβestablished risk factors for thrombosis in essential thrombocythemia (ET) and polycythemia vera (PV); cytoreductive therapy was indicated in their presence. Recent studies have suggested leukocytosis as an additional ris
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