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Essential role of tumor necrosis factor α in alcohol-induced liver injury in mice

✍ Scribed by Ming Yin; Michael D. Wheeler; Hiroshi Kono; Blair U. Bradford; Randle M. Gallucci; Michael I. Luster; Ronald G. Thurman

Book ID
118021415
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
531 KB
Volume
117
Category
Article
ISSN
0016-5085

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Although hepatic ischemia-reperfusion (IR) injury is partially mediated by tumor necrosis factor-alpha (TNF), we recently found that low-dose TNF before IR is hepatoprotective. We examined the seemingly conflicting roles of TNF in mediating liver injury in a partial hepatic IR model using TNF gene k