Essential role of receptor for advanced glycation end products (RAGE) in the inflammatory response and mucosal injury after hemorrhagic shock (HS)
β Scribed by Kathleen Raman; Penny Sappington; Runkuan Yang; Fang Liu; Leo Otterbein; Ann Marie Schmidt; Mitchell P. Fink; Timothy R. Billiar
- Book ID
- 113675986
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 53 KB
- Volume
- 199
- Category
- Article
- ISSN
- 1072-7515
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π SIMILAR VOLUMES
Multiligand receptor for advanced glycation end products (RAGE) is expressed in a wide variety of tissues, including the liver. Interactions with its ligands lead to cellular activation and thus prolonged inflammation and apoptosis. RAGE also exists in a soluble, truncated isoform called soluble RAG
Hepatic ischemia/reperfusion (I/R) injury associated with liver transplantation and hepatic resection is characterized by hepatocellular damage and a deleterious inflammatory response. In this study, we examined whether receptor for advanced glycation end product (RAGE) activation is linked to mecha