Escape phenomenon occurs by lowering cholesterol with a hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor in patients with familial hypercholesterolemia

Lipid-lowering response of the HMG-CoA r

Lipid-lowering response of the HMG-CoA reductase inhibitor fluvastatin is influenced by polymorphisms in the low-density lipoprotein receptor gene in Brazilian patients with primary hypercholesterolemia

✍ Luis A. Salazar; Mario H. Hirata; Éder C.R. Quintão; Rosario D.C. Hirata 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 63 KB 👁 2 views

Although the efficacy of fluvastatin (HMG-CoA reductase inhibitor) in the treatment of primary hypercholesterolemia is well documented, a wide interindividual variation treatment response has been observed. We have studied the possible role of the AvaII (exon 13), HincII (exon 12), and PvuII (intron