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Erythropoietin reduces anemia and transfusions : A randomized trial with or without erythropoietin during chemotherapy

✍ Scribed by Frank R. Dunphy; Bruce R. Harrison; Teresa L. Dunleavy; Jack J. Rodriguez; Jack G. Hilton; James H. Boyd

Book ID: 101230773
Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 88 KB
Volume: 86
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19991001)86:7<1362::aid-cncr36>3.0.co;2-t

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✦ Synopsis

BACKGROUND.

Anemia has been reported to develop during preoperative chemotherapy with paclitaxel and carboplatin. The use of recombinant human erythropoietin (EPO) has been shown to reduce anemia and subsequent packed red blood cell transfusions. The current study is a report of a Phase III, prospective, randomized trial with or without EPO that confirms the original observations of less anemia and fewer transfusions in those patients randomized to receive EPO concurrently with paclitaxel and carboplatin.

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