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Erythropoietin Overcomes Imatinib-Induced Apoptosis and Induces Erythroid Differentiation in TF-1/bcr-abl Cells

โœ Scribed by Mie Uchida; Tomoko Watanabe; Masae Kunitama; Masaki Mori; Satoru Kikuchi; Kozue Yoshida; Keita Kirito; Tadashi Nagai; Keiya Ozawa; Norio Komatsu


Book ID
111845967
Publisher
AlphaMed Press
Year
2004
Tongue
English
Weight
771 KB
Volume
22
Category
Article
ISSN
1066-5099

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## Abstract We compare the effects of Imatinib mesylate (Glivecยฎ) on chronic myeloid leukemia derived cell lines K562 and JURLโ€MK1. In both cell lines, the cell cycle arrests in G~1~/G~0~ phase within 24 h after the addition of 1 ฮผM Imatinib. This is followed by a decrease of Kiโ€67 expression and t