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Erythromycin inhibits the assembly of the large ribosomal subunit in growingEscherichia colicells

โœ Scribed by Harold S. Chittum; W. Scott Champney

Book ID
104709656
Publisher
Springer
Year
1995
Tongue
English
Weight
636 KB
Volume
30
Category
Article
ISSN
0343-8651

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Binding of erythromycin to the 50S ribos
Binding of erythromycin to the 50S ribosomal subunit is affected by alterations in the 30S ribosomal subunit
โœ Saltzman, Larry ;Apirion, David ๐Ÿ“‚ Article ๐Ÿ“… 1976 ๐Ÿ› Springer ๐ŸŒ English โš– 644 KB

Expression of resistance to erythromycin in Escherichia coli, caused by an altered L4 protein in the 50S ribosomal subunit, can be masked when two additional ribosomal mutations affecting the 30S proteins S5 and S12 are introduced into the strain (Saltzman, Brown, and Apriion, 1974). Ribosomes from