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Erythroid differentiation and growth inhibition of K562 cells by 2′,5′-dideoxyadenosine: Synergism with interferon-α

✍ Scribed by Kazuei Ogawa; Masaro Tashima; Yasushi Takeda; Hirofumi Sawai; Tomoko Toi; Hiroyoshi Sawada; Yukio Maruyama; Minoru Okuma


Book ID
113240105
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
957 KB
Volume
19
Category
Article
ISSN
0145-2126

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Upon appropriate drug treatment, the human erythroleukemic K562 cells have been shown to produce hemoglobin and F-cells. Fetal hemoglobin (Hb F) inhibits the polymerization events of sickle hemoglobin (Hb S), thereby ameliorating the clinical symptoms of sickle cell disease. Ribonucleotide reductase