We have compared the solubility, kinetic, immunological, and electrophoretic properties of erythrocyte pyruvate kinase from normal dogs and Basenji dogs with congenital hemolytic anemia due to pyruvate kinase deficiency. Differences can be detected between the two enzymes by all methods. The enzyme
โฆ LIBER โฆ
Erythrocytic Pyruvate Kinase Mutations Causing Hemolytic Anemia, Osteosclerosis, and Secondary Hemochromatosis in Dogs
โ Scribed by G. Inal Gultekin; K. Raj; P. Foureman; S. Lehman; K. Manhart; O. Abdulmalik; U. Giger
- Book ID
- 114952013
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 508 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0891-6640
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## Communicated by Mark Paalman Pyruvate kinase (PK) deficiency (PKD) is an autosomal recessive disorder with the typical manifestation of nonspherocytic hemolytic anemia. We analyzed the mutant enzymes of 10 unrelated patients with PKD, whose symptoms ranged from a mild, chronic hemolytic anemia t