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Erythrocytic glutathione reductase deficiency in a hospital population in the united states

✍ Scribed by Dr. Henri Frischer

Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
452 KB
Volume
2
Category
Article
ISSN
0361-8609

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

In the USA, erythrocytic glutathione reductase (GSSG‐R) deficiency is significantly more common, and can be considerably more pronounced in hospitalized patients (118/3198) than in outpatients (37/1639) or in apparently healthy persons (12/849). Retrospective analysis of illnesses found in 118 inpatients with erythrocytic GSSG‐R deficiency revealed a striking and previously unsuspected association of the enzyme deficiency with a variety of chemotherapeutically treated hematological or nonhematological malignancies (51/118 patients, 43.2%, or 51/170 diagnoses, 30.0%). The prevalence of erythrocytic GSSG‐R deficiency also increased in malnutrition, liver disease, and sepsis. Drugs of the nitrosourea class, particularly BCNU [1, 3‐bis(2‐chloroethyl)‐1‐nitrosourea] are causally implicated in the association of GSSG‐R deficiency with malignancies. Severe or complete GSSG‐R deficiency may handicap host response to infections.

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