Erythrocyte uroporphyrinogen synthase activity as a possible diagnostic aid in the diagnosis of lymphoproliferative diseases
✍ Scribed by Orit Epstein; Meir Lahav; Nili Schoenfeld; Lila Nemesh; Mati Shaklai; Abraham Atsmon
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 446 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
Patients with active lymphoproliferative diseases were shown to have high activity of erythrocyte uroporphyrinogen synthetase (URO-S), the enzyme which converts porphobilinogen to uroporphyrinogen. In a few patients examined the lymphocyte URO-S was markedly increased. No correlation was found between the high URO-S activity and the degree of anemia, reticulocytosis, or the presence of hemolysis. Patients with epithelial malignancies and with some common viral diseases had normal erythrocyte URO-S values. Three patients with nonalcoholic cirrhosis also had high erythrocyte URO-S activities. The determination of erythrocyte and lymphocyte URO-S activity may be of aid in the diagnosis of lymphoproliferative diseases. It may also indicate whether remission has been achieved and whether treatment should be continued or reinstituted. These preliminary observations justify the investigation of a larger patient and control material.
Cancer 52:828-832, 1983.
T WAS SHOWN by Sassa and associates that lymphocyte
an inducible enzyme and that induction can be achieved by adding a mitogenic drug to a suspension of lymphocytes.' In view of these observations, we decided to investigate URO-S activity in lymphocytes of patients with various lymphoproliferative diseases (LPD). When the first patients examined were shown to have a markedly elevated activity, their erythrocytes were also examined and a high URO-S activity was observed. Since determination of URO-S in erythrocytes is both less time consuming and easier than in lymphocytes, erythrocyte URO-S activity was determined in a group of patients with LPD, in a control group and in patients with various other diseases. This preliminary report describes the results of this investigation.
Patients and Methods
Twenty-nine patients with lymphoproliferative diseases, 13 males and 16 females, aged 32 to 70 years, From