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Erythrocyte nucleotides in lead workers

โœ Scribed by Masayoshi Ichiba; Katsumaro Tomokuni; Koji Mori

Book ID
104750437
Publisher
Springer-Verlag
Year
1992
Tongue
English
Weight
248 KB
Volume
63
Category
Article
ISSN
0340-0131

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โœฆ Synopsis

We determined erythrocyte nucleotides levels in 22 lead workers with blood lead ranging from 8 to 78 jgldl Their erythrocyte pyrimidine 5 '-nucleotidase (P 5 N) activity ranged from 19 4 to 3 4 z mol uridine/h per g hemoglobin A significant elevation of erythrocyte pyrimidine nucleotides was found, and their contents correlated inversely with erythrocyte P 5 N activity and positively with blood lead concentration In particular, the contents of uridine triphosphate (UTP) and cytidine triphosphate (CTP) exhibited a high correlation with P 5 N activity (r = -0 56, -0 54) However, its concentration in lead workers was estimated to be much lower than that in hereditary P 5 N deficiency.

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