Erythrocyte catalase mutant in Swisstype acatalasemia
β Scribed by E. Shapira; H. Abei
- Book ID
- 118538338
- Publisher
- Elsevier Science
- Year
- 1974
- Tongue
- English
- Weight
- 222 KB
- Volume
- 84
- Category
- Article
- ISSN
- 1097-6833
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π SIMILAR VOLUMES
In Japanese-type acatalasemia erythrocytes, the presence and properties of residual catalase were determined and compared with those of normal erythrocyte catalase. Residual catalase activity was proved by titration, active staining after polyacrylamide gel electrophoresis, and measurement of oxygen
The unstable catalase variant found in the blood of individuals homozygous for Swiss-type acatalasemia and the enzyme species present in heterozygous carriers of this rare defect have been further characterized. The mutant enzyme isolated from acatalasemic red cells is considerably more heat labile