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Erythrocyte as a potential model for study of lifelong somatic mutations

✍ Scribed by B.I. Gerashchenko

Book ID: 117495307
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 112 KB
Volume: 51
Category: Article
ISSN: 0306-9877
DOI: 10.1016/s0306-9877(98)90108-6

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During the development of cancer a series of specific genetic alterations have to occur in a stepwise fashion to transform a normal somatic cell into a malignant tumor cell. These genetic changes can be roughly divided in two groups: mutations in proto-oncogenes that result in a constantly activated