✦ LIBER ✦

ERV3 Human endogenous provirus mRNAs are expressed in normal and malignant tissues and cells, but not in choriocarcinoma tumor cells

✍ Scribed by Maurice Cohen; Nobuyuki Kato; Erik Larsson

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 515 KB
Volume: 36
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.240360203

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✦ Synopsis

Messenger RNA expression of a human endogenous provirus, ERV3, has been characterized in 170 specimens of normal and malignant human tissues and cells. In contrast to the high expression in first-trimester and full-term placental chorionic villi, most other human tissues expressed ERV3 mRNAs at a level of 2-30% of placenta. However, ERV3 mRNAs were not detected in choriocarcinoma tumor cell lines. These studies suggest that the ERV3 provirus may have been preempted for a biological function and disruption of its mRNA expression results in choriocarcinoma.

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