Erratum to “Salarin C, a new cytoxic sponge-derived nitrogenous macrolide” [Tetrahedron Lett. 49 (2008) 4355]
✍ Scribed by Ashgan Bishara; Amira Rudi; Maurice Aknin; Drorit Neumann; Nathalie Ben-Califa; Yoel Kashman
- Book ID
- 104095578
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- French
- Weight
- 117 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The editors and publishers regret that in the above Letter concentrations of the active compounds were erroneously given in millimolars (mM) rather than in micromolars (lM) and in mg/ml rather than in lg/ml. The penultimate sentence of the Abstract and the passage 'The anti-proliferative activity of salarin C was dose-dependent. . . (e.g., geldanamycin) 19 ' on p 4357 are corrected as follows:
'Salarin C was found to inhibit cell proliferation of human leukeamic cell lines UT-7 and K562 and the murine pro-B cell line Ba/F3 at concentrations of 0.0005-0.5 lg/ml'.
'The anti-proliferative activity of salarin C was dose-dependent; salarin C at concentrations of 0.0005-0.5 lg/ml was added to the cells for 24 h, and cell viability was determined by MTT assay. 18 Salarin C was by far more potent than salarins A and B, and tulearin A, 50% inhibition of cell proliferation was obtained at 0.5 lg/ml (1 lM) of salarin C for the UT-7 cell line and at 0.05 lg/ml (0.1 lM) for the K562 cell line. The sensitivity of the Ba/F3 cells was much higher as their proliferation was arrested completely at 0.1 lM of salarin C. The effective concentration range of salarin C (IC 50 0.1-1 lM) is comparable, and even lower than those of other chemotherapeutic agents (e.g., geldanamycin).