Erratum to: Phenotypic and genetic characterization of varicella-zoster virus mutants resistant to acyclovir, brivudine and/or foscarnet
โ Scribed by Karoline Bleymehl, Jindrich Cinatl, Jonas Schmidt-Chanasit
- Book ID
- 113042515
- Publisher
- Springer-Verlag
- Year
- 2012
- Tongue
- English
- Weight
- 245 KB
- Volume
- 201
- Category
- Article
- ISSN
- 0300-8584
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A man with acquired immunodeficiency syndrome (AIDS) developed zoster of the right arm which was resistant clinically to acyclovir. Varicella-zoster virus (VZV) was cultured from a skin biopsy performed at the beginning of acyclovir therapy (isolate 1) and after its failure (isolate 2). The emergenc
Seven independent laboratory mutants were derived from seven distinct wild-type varicellazoster virus (VZV) isolates after exposure to increasing concentrations of foscarnet (PFA) and were found to be resistant to this drug. Single base changes resulting in amino acid substitutions were observed in