A general route to 5-substituted-2-furyl
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Simon J. Hayes; David W. Knight; Andrew W.T. Smith; Mark J. O’Halloran
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Article
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2010
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Elsevier Science
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French
⚖ 278 KB
a b s t r a c t 3,4-Dihydroxy-5-alkynylcarboxylic acids, readily obtained by the addition of lithium acetylides to a-acetoxysuccinic anhydride followed by reduction and hydrolysis, undergo smooth silver(I)-catalysed 5-endodig cyclisations and in situ dehydration to give excellent overall yields of 5