Phase I/II study of subcutaneous homohar
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Alfonso Quintás-Cardama; Hagop Kantarjian; Guillermo Garcia-Manero; Susan O'Brie
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Article
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2007
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John Wiley and Sons
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English
⚖ 103 KB
## Abstract ## BACKGROUND. Homoharringtonine (HHT) is a cephalotaxus alkaloid that inhibits the synthesis of proteins leading to apoptosis. Intravenous HHT has demonstrated activity in patients with chronic myeloid leukemia (CML) after failure with interferon. ## METHODS. A Phase I study was com