PNPLA3 (adiponutrin), a novel patatin-like phospholipase domain-containing enzyme, is expressed at high level in fat, but also in other tissues including liver. Polymorphisms in PNPLA3 have been linked to obesity and insulin sensitivity. Notably, a nonsynonymous variant rs738409(G) allele of the PNP
Erratum: Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease
โ Scribed by Weiqin Chen; Benny Chang; Lan Li; Lawrence Chan
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 35 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0270-9139
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โฆ Synopsis
In the September 2010 issue of HEPATOLOGY (volume 52, number 3), in the article entitled ''Patatin-Like Phospholipase Domain-Containing 3/Adiponutrin Deficiency in Mice Is Not Associated With Fatty Liver Disease'' (pages 1134-1142) the second sentence of the financial support footnote should be changed to ''W.C. was supported in part by a mentor-based postdoctoral fellowship from the American Diabetes Association (no. 7-06-MN-10) and by a postdoctoral fellowship from the American Heart Association (no. 0825134 F).''
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Inherited factors play a major role in the predisposition to nonalcoholic fatty liver disease (NAFLD), and the rs738409 CfiG polymorphism of PNPLA3/adiponutrin, encoding for the isoleucine-to-methionine substitution at residue 148 (I148M) protein variant, has recently been recognized as a major dete
Genome-wide association studies identified single-nucleotide polymorphisms (SNPs) that are associated with increased hepatic fat or elevated liver enzymes, presumably reflecting nonalcoholic fatty liver disease (NAFLD). To investigate whether these SNPs are associated with histological severity of N