Genome-wide tissue-specific farnesoid X
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Ann M. Thomas; Steven N. Hart; Bo Kong; Jianwen Fang; Xiao-bo Zhong; Grace L. Gu
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Article
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2009
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John Wiley and Sons
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English
β 648 KB
Farnesoid X receptor (FXR) is a bile acid-activated transcription factor belonging to the nuclear receptor superfamily. FXR is highly expressed in liver and intestine and crosstalk mediated by FXR in these two organs is critical in maintaining bile acid homeostasis. FXR deficiency has been implicate