Accumulation of CO 2 in animal cell cultures can be a significant problem during scale-up and production of recombinant glycoprotein biopharmaceuticals. By examining the cell-surface polysialic acid (PSA) content, we show that elevated CO 2 partial pressure (pCO 2 ) can alter protein glycosylation.
Erratum: Effects of elevated pCO2 and/or osmolality on the growth and recombinant tPA production of CHO cells
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 15 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0006-3592
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