Ergoline alkaloidal constituents of hawaiian baby wood rose, argyreia nervosa (Burm. f.) bojer
✍ Scribed by Jew-Ming Chao; Ara H. Der Marderosian
- Book ID
- 102404270
- Publisher
- John Wiley and Sons
- Year
- 1973
- Tongue
- English
- Weight
- 437 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
Chemical analysis showed that the seeds of Argyreia nervosa contain the highest percentage of indole alkaloid constituents (0.5-0.9$) of the genera of the Convolvulaceae thus far studied. A total of 19 indole alkaloids were identified by thin-layer and paper chromatographic procedures. Of these, lysergene, festuclavine, setoclavine, isosetoclavine, agroclavine, elymoclavine, crgine, and isoergine were isolated by column chromatographic procedures and characterized by TLC and IR analyses. Penniclavine, chanoclavine-I, chanoclavine-11, ergometrine, ergometrinine, lysergic acid a-hydroxyethylamide, isolysergol, racemic chanoclavine-11, molliclavine, lysergol, and isolysergic acid a- hydroxyethylamide were identified by TLC only. Of these, lysergene, setoclavine, isosetoclavine, chanoclavine-11, racemic chanoclavine-11, isolysergol, and molliclavine were identified for the first time in species of the Convolvulaceae. Ergine (0.136%) and isoergine (0.188 $) were found in the highest concentration. In addition, 11 unidentified indole alkaloids were detected, these being found in very low concentration. Although the pericarp showed the same alkaloid pattern as the seeds, the concentration was much lower (0.0015%). No alkaloids could be detected in the vegetative tissues of nonflowering specimens.
Keyphrases 0 Alkaloidal constituents, Argyreia nervosa seedsisolation, identification of 19 indole alkaloids 0 Argyreia nervosa (Burm. f.) Bojer seeds-isolation, identification of 19 indole alkaloids 0 Morning-glory seeds-isolation, identification of 19 indole alkaloids Ergoline alkaloids-isolation, identification from Argyreia nervosa (morning-glory) Argyreia neruosa (Burm. f.) Bojer is a member of the Convolvulaceae (morning-glory family) and is characterized by heart-shaped leaves with dense, white, silky hairs beneath. The plant is believed to have its origin in India. Historically, its roots have been used by the Hindus as an alternative, tonic, antirheumatic and in the treatment of diseases of the nervous system (1). The leaves have been used as a local stimulant, rubefacient, and vesicant. Because the under surface of the leaf is covered by a thick layer of silky hairs, it has been used as a natural impermeable temporary covering and poultice for minor skin abrasions by natives in India. However, Dymock (2) reported the leaves to be ineffective for this purpose.
This species is commonly and widely cultivated as a garden plant in several tropical countries because of its showy flowers. The mature capsules are handsome and persistent and are widely used in ornamental driedflower arrangements. To date, no significant pharmacological or phytochemical studies on A . nervosa have appeared in the literature.
Since Aztec times in the uplands of southern Oxaca in Mexico, the seeds of Rhea corymhosa (known as "Ololiuqui") and Ipomoea uiolacea (known as "badoh negro") have been used for divinatory and hallucinatory purposes during religious ceremonies. The native use of these seeds for ceremonial purposes was extensively reported by Schultes (3-5) and Wasson (6). Following these publications, there occurred a rash of use of