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ERE-independent ERα target genes differentially expressed in human breast tumors

✍ Scribed by Christine Glidewell-Kenney; Jeffrey Weiss; Eun-Jig Lee; Suresh Pillai; Toshio Ishikawa; Eric A. Ariazi; J. Larry Jameson

Book ID: 116733780
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 314 KB
Volume: 245
Category: Article
ISSN: 0303-7207
DOI: 10.1016/j.mce.2005.10.003

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## Abstract ETV1 (ER81) is a transcription factor that can be activated by HER2/Neu, a proto‐oncoprotein often overexpressed in metastatic breast tumors. Here, we demonstrate that ETV1 downregulation suppresses proliferation of HER2/Neu‐positive MDA‐MB‐231 breast cancer cells in vitro and tumor for