ERCC6/CSB gene polymorphisms and lung cancer risk
β Scribed by Hongxia Ma; Zhibin Hu; Haifeng Wang; Guangfu Jin; Ying Wang; Weiwei Sun; Dan Chen; Tian Tian; Li Jin; Qingyi Wei; Daru Lu; Wei Huang; Hongbing Shen
- Book ID
- 116334946
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 154 KB
- Volume
- 273
- Category
- Article
- ISSN
- 0304-3835
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Empty boxes indicate unavailable data. Patients are presented according to clinical severity. GenBank accession numbers NT\_006713.15 and NM\_000082.3 have been used as reference sequences for the CSA gene and the CSA cDNA respectively. Nucleotide numbering reflects cDNA numbering with 11 correspond
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Cockayne syndrome B protein (ERCC6) plays an essential role in DNA repair. However, the Cockayne syndrome caused by the ERCC6 defect has not been linked to cancer predisposition; likely due to the fact that cells with severe disruption of the ERCC6 function are sensitive to lesion-induced apoptosis,
## Abstract __O^6^__βalkylguanineβDNA alkyltransferase (AGT) plays an important role in the repair of __O^6^__βalkylguanine adducts, which are major mutagenic lesions produced by environmental carcinogens. Polymorphisms in the __AGT__ gene may affect the capacity to repair DNA damage and thereby ha