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ERCC1 Asn118Asn polymorphism as predictor for cancer response to oxaliplatin-based chemotherapy in patients with advanced colorectal cancer

✍ Scribed by Jun Liang; Hongying Lv; Ruyong Yao; Hua Liang; Gang Wu


Publisher
Springer
Year
2008
Tongue
English
Weight
415 KB
Volume
7
Category
Article
ISSN
1610-1979

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## Abstract Thymidylate synthase (TS) is the primary target of 5‐fluorouracil (5‐FU). A VNTR polymorphism in the TS promoter region is associated with the efficacy of 5‐FU‐based chemotherapy in colorectal cancer. A common G>C SNP at the 12th nucleotide of the second repeat in the TS\*3 alleles has