ERBB3 kinase domain mutations are rare in lung, breast and colon carcinomas

Mutations of the CHK2 gene are found in

Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors

✍ Carl W. Miller; Takayuki Ikezoe; Utz Krug; Wolf-K. Hofmann; Sigal Tavor; Vijaya 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 92 KB

## Abstract Checkpoint genes, activated in response to DNA damage and other stresses, are frequently targeted for alteration in cancer. Checkpoint kinase 2 (__CHK2, CDS1, RAD53__) is activated by ataxia telangiectasia mutated (ATM) in response to γ irradiation. Activated __CHK2__ stabilizes TP53, a