Erasure of methylation imprinting of Igf2r during mouse primordial germ-cell development
β Scribed by Shun Sato; Tomomi Yoshimizu; Eimei Sato; Yasuhisa Matsui
- Book ID
- 111661898
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 427 KB
- Volume
- 65
- Category
- Article
- ISSN
- 1040-452X
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## Abstract Studies examining altered imprinted gene expression in cancer compare the observed expression pattern to the normal expression pattern for a given tissue of origin, usually the somatic expression pattern for the imprinted gene. Germ cell tumors (GCTs), however, require a developmental s
## Abstract Previous studies have demonstrated biallelic expression of the imprinted genes __H19__ and __IGF2__ and loss of DNA methylation of the __SNRPN__ gene, indicating a common precursor cell of human germ cell tumors (GCTs), namely, the primordial germ cell (PGC). In this study, we applied t