ER Stress Regulation of ATF6 Localization by Dissociation of BiP/GRP78 Binding and Unmasking of Golgi Localization Signals

Down-regulation of epidermal growth fact

Down-regulation of epidermal growth factor receptor-signaling pathway by binding of GRP78/BiP to the receptor under glucose-starved stress conditions

✍ Bing Cai; Akihiro Tomida; Koji Mikami; Kazuhiro Nagata; Takashi Tsuruo 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 166 KB

GRP78/BiP, a molecular chaperone in the endoplasmic reticulum, is induced under such adverse conditions for cell survival as glucose starvation. Induction of GRP78 has been shown to coincide with G1 cell cycle arrest, which is an important cellular defense system. In this study, we investigated invo