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ER aminopeptidases generate a unique pool of peptides for MHC class I molecules

✍ Scribed by Serwold, Thomas; Gaw, Stephanie; Shastri, Nilabh


Book ID
109831893
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
348 KB
Volume
2
Category
Article
ISSN
1529-2908

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he allele-specific peptidebinding motifs of major histocompatibility complex (MHC) proteins, originally discovered by pool sequencing of MHC class I-bound peptides 1 , provide a biochemical basis for the phenomenon of MHC restriction of T-cell responses. However, the analysis of class II peptide mot