✦ LIBER ✦

Equine metabolism of buspirone studied by high-performance liquid chromatography/mass spectrometry

✍ Scribed by Stanley, S. M. R.

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 142 KB
Volume: 35
Category: Article
ISSN: 1076-5174
DOI: 10.1002/(sici)1096-9888(200003)35:3<402::aid-jms950>3.0.co;2-l

No coin nor oath required. For personal study only.

✦ Synopsis

The metabolism and urinary excretion of a 100 mg dose of the non-sedating anxiolytic drug buspirone was examined using high-performance liquid chromatography/electrospray ionization mass spectrometry in the positive ion mode. In addition to a significant proportion of unchanged buspirone we were able to detect three major metabolite classes. These were identified as monohydroxy, dihydroxy and dihydroxymethoxy products. Detection of the metabolites and the parent drug was possible in all the urine samples collected (1-12 h) post-administration.

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