Analysis of the Kinetic and Equilibrium
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ALEXANDER TAGHVA; YUNMEI MA; MICHAEL R. LIEBER
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Article
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2002
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Elsevier Science
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English
β 253 KB
The loading of Ku onto a DNA end in a double-strand DNA break is thought to be one of the "rst steps in the non-homologous DNA end joining (NHEJ) pathway, giving it an essential role in the maintenance of genomic integrity. The binding of Ku to DNA is complicated since DNA can accommodate multiple K