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Equilibrium and kinetic studies on the binding of des-N-tetramethyltriostin A to DNA

✍ Scribed by K.R. Fox; R.K. Olsen; M.J. Waring


Book ID
119118969
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
590 KB
Volume
696
Category
Article
ISSN
0167-4781

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The loading of Ku onto a DNA end in a double-strand DNA break is thought to be one of the "rst steps in the non-homologous DNA end joining (NHEJ) pathway, giving it an essential role in the maintenance of genomic integrity. The binding of Ku to DNA is complicated since DNA can accommodate multiple K