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Equilibrium and Kinetic Analysis of Nucleotide Binding to the DEAD-Box RNA Helicase DbpA †

✍ Scribed by Talavera, Miguel A.; De La Cruz, Enrique M.


Book ID
126974287
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
237 KB
Volume
44
Category
Article
ISSN
0006-2960

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The loading of Ku onto a DNA end in a double-strand DNA break is thought to be one of the "rst steps in the non-homologous DNA end joining (NHEJ) pathway, giving it an essential role in the maintenance of genomic integrity. The binding of Ku to DNA is complicated since DNA can accommodate multiple K