Equilibrative nucleoside transporter 2 is expressed in human umbilical vein endothelium, but is not involved in the inhibition of adenosine transport induced by hyperglycaemia

Insulin restores glucose inhibition of a

Insulin restores glucose inhibition of adenosine transport by increasing the expression and activity of the equilibrative nucleoside transporter 2 in human umbilical vein endothelium

✍ Gonzalo Muñoz; Rody San Martín; Marcelo Farías; Luis Cea; Andrea Vecchiola; Paol 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 365 KB

## Abstract L‐Arginine transport and nitric oxide (NO) synthesis (L‐arginine/NO pathway) are stimulated by insulin, adenosine or elevated extracellular D‐glucose in human umbilical vein endothelial cells (HUVEC). Adenosine uptake via the human equilibrative nucleoside transporters 1 (hENT1) and 2 (