Equations for estimation of first-pass effect and apparent distribution volume of drug with incomplete oral absorption and partial renal excretion

A convenient method for estimating the q

A convenient method for estimating the quantity of drug eliminated by the routes other than hepatic metabolism and renal excretion and the fraction of drug that reaches the “first pass” after oral administration

✍ Leonid M. Berezhkovskiy 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 117 KB 👁 1 views

The comparison of routine pharmacokinetic data obtained after intravenous and oral drug administration allows to figure out that some quantity of drug, which reached the systemic circulation, was eliminated from the body by routes other than hepatic metabolism and renal excretion. This quantity is e