Epstein Barr Virus Volume 1: One Herpes Virus: Many Diseases

✍ Scribed by Christian Münz (eds.)

• Publisher: Springer International Publishing
• Year: 2015
• Tongue: English
• Leaves: 387
• Series: Current Topics in Microbiology and Immunology 390
• Edition: 1
• Category: Library

✦ Synopsis

Epstein Barr virus (EBV) was discovered as the first human tumor virus around 50 years ago. Since its discovery in Burkitt’s lymphoma it has been associated with various other malignancies, infectious mononucleosis and even autoimmune diseases. The two book volumes on EBV summarize the first 50 years of research on this tumor virus, starting with historical perspectives on discovery, oncogenicity and immune control, reviewing the role that the virus plays in the various associated diseases and concluding with a discussion on how the immune system keeps persistent EBV infection under control in healthy EBV carriers and can be used to treat EBV associated diseases. The respective 32 chapters are written by international experts from three continents for health care providers, biomedical researchers and patients that are affected by EBV. The assembled knowledge should help to understand EBV associated diseases better and to develop EBV specific vaccination in the near future.

✦ Table of Contents

Front Matter....Pages i-viii
Front Matter....Pages 1-1
Why and How Epstein-Barr Virus Was Discovered 50 Years Ago....Pages 3-15
Tumor Associations of EBV—Historical Perspectives....Pages 17-22
EBV-Specific Immune Response: Early Research and Personal Reminiscences....Pages 23-42
Front Matter....Pages 43-43
Epstein–Barr Virus Strain Variation....Pages 45-69
Chromatin Structure of Epstein–Barr Virus Latent Episomes....Pages 71-102
The Epigenetic Life Cycle of Epstein–Barr Virus....Pages 103-117
Epstein–Barr Virus: From the Detection of Sequence Polymorphisms to the Recognition of Viral Types....Pages 119-148
Front Matter....Pages 149-149
EBV Persistence—Introducing the Virus....Pages 151-209
Infectious Mononucleosis....Pages 211-240
Primary Immunodeficiencies Associated with EBV Disease....Pages 241-265
Burkitt’s Lymphoma....Pages 267-285
Contribution of the Epstein-Barr Virus to the Pathogenesis of Hodgkin Lymphoma....Pages 287-313
The Role of EBV in the Pathogenesis of Diffuse Large B Cell Lymphoma....Pages 315-337
Nasopharyngeal Carcinoma: An Evolving Role for the Epstein–Barr Virus ....Pages 339-363
EBV and Autoimmunity....Pages 365-385
Back Matter....Pages 387-391

✦ Subjects

Virology