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Epstein-Barr Virus Transactivates the Human Endogenous Retrovirus HERV-K18 that Encodes a Superantigen

โœ Scribed by Natalie Sutkowski; Bernard Conrad; David A Thorley-Lawson; Brigitte T Huber

Book ID
117723120
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
352 KB
Volume
15
Category
Article
ISSN
1074-7613

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Epstein-Barr virus (EBV) is a human tumour virus that efficiently growth-transforms primary human B-lymphocytes in vitro. The viral nuclear antigen 2 (EBNA2) is essential for immortalisation of B-cells and stimulates viral and cellular gene expression through interaction with DNA-bound transcription