Epstein-Barr Virus Protocols Volume 174 || Generation of Lymphoblastoid Cell Lines (LCLs)
โ Scribed by Wilson, Joanna B.; May, Gerhard H. W.
- Book ID
- 124076902
- Publisher
- Humana Press
- Year
- 2001
- Weight
- 87 KB
- Category
- Article
- ISBN-13
- 9781592592272
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## Abstract Human lymphoblastoid lines of various origins which harbour EpsteinโBarr virus (EBV)โspecific nucleic acid were reโexposed to EBV. Following infection, cells of the nonโvirusโproducing lines, Raji and S 95, predominantly synthesized EBVโspecific early antigens (EA), whereas only a small
In order t o examine the role of Epstein-Barr virus (EBV) in the immortalization of human B lymphocytes and in the pathogenesis of lymphoid malignancies, we investigated whether the EBV integration into the human genome is randomly distributed or whether the virus integrates preferentially at certai