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Epstein-barr virus internalization and infectivity are blocked by selective protein kinase C inhibitors

✍ Scribed by Mara Cirone; Antonio Angeloni; Giuseppe Barile; Claudia Zompetta; Marco Venanzoni; Maria Rosaria Torrisi; Luigi Frati; Alberto Faggioni

Book ID
102865277
Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
535 KB
Volume
45
Category
Article
ISSN
0020-7136

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✦ Synopsis

Selective protein kinase C inhibitors can either block or significantly reduce Epstein-Barr virus infectivity: inhibition of transformation and decreased 3H-thymidine CH-TdR) incorporation in human B lymphocytes infected with B95-8 EBV, as well as a significant reduction in the induction of early antigens in Raji cells superinfected by P3HRI EBV was achieved by pre-treating the cells with the inhibitors. The inhibitors do not act by blocking binding of the virus to its cellular receptor CR 2, but rather are effective in the viral internalization process. Our results suggest that protein kinase C may be involved in the process of viral entry into cells. 3To whom reprint requests should be sent

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We have shown that modulation of intracellular calcium in EBV latently infected cells could induce the expression of viral antigens, and suggested that a protein kinase-C (PKC) may play a major role in the EBV genome activation. We now report further investigations on the role of PKC using 2 selecti