✦ LIBER ✦

Epstein-Barr virus genomes are found predominantly in IgA-positive B cells in the blood of healthy carriers

✍ Scribed by Barbro Ehlin-Henriksson; Jie-Zhi Zou; George Klein; Ingemar Ernberg

Publisher: John Wiley and Sons
Year: 1999
Tongue: French
Weight: 668 KB
Volume: 83
Category: Article
ISSN: 0020-7136
DOI: 10.1002/(sici)1097-0215(19990924)83:1<50::aid-ijc10>3.0.co;2-1

No coin nor oath required. For personal study only.

✦ Synopsis

B lymphocytes have been identified as the main reservoir of latent Epstein-Barr virus (EBV) in healthy virus carriers. We have established a semi-quantitative PCR method to estimate the EBV genome load in the blood B-cell subpopulation in healthy individuals. EBV DNA was detected in subfractionated IgM-, IgG-and IgA-positive B cells. Between 80% and 90% of the viral DNA was found in the IgA-positive compared with the IgA-negative fraction.

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