✦ LIBER ✦

Epstein-barr virus (EBV) antibody in patients treated by radical radiotherapy for head and neck cancer

✍ Scribed by Marlene R. Halili; Ilya Spigland; Nan Foster; Nemetallah A. Ghossein

Publisher: John Wiley and Sons
Year: 1978
Tongue: English
Weight: 384 KB
Volume: 10
Category: Article
ISSN: 0022-4790
DOI: 10.1002/jso.2930100511

No coin nor oath required. For personal study only.

✦ Synopsis

Antibody against Epstein Barr Viral capsid (EBV-VCA) was measured in 65 patients with primary head and neck cancer referred for radical radiotherapy. Sixty-three percent had locally advanced cancer and 37% had early disease. Forty-eight percent had detectable antibody in their sera. Thirty-three percent had elevated titers (above 1:20 dilution). Only 19% of cases with early cancer had increased titers. Almost 50% of those with locally advanced cancer or recurrence following treatment had titers above 1:20. A rise in titer within six months following radiotherapy was associated with a significant incidence of recurrence. There was no correlation between delayed hypersensitivity skin reaction to 2--4 dinitrochlorobenzene (DNCB) and titer values. EBV-VCA may be an additional parameter which can be used to determine host defenses in patients with malignancies.

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