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Epstein-barr virus and cytomegalovirus in relation to testicular-cancer risk: a nested case-control study

✍ Scribed by Olof Akre; Loren Lipworth; Steinar Tretli; Annika Linde; Lars Engstrand; Hans-Olov Adami; Mads Melbye; Aage Andersen; Anders Ekbom

Publisher: John Wiley and Sons
Year: 1999
Tongue: French
Weight: 49 KB
Volume: 82
Category: Article
ISSN: 0020-7136
DOI: 10.1002/(sici)1097-0215(19990702)82:1<1::aid-ijc1>3.0.co;2-l

No coin nor oath required. For personal study only.

✦ Synopsis

An infectious etiology of testicular cancer has been suggested. We have evaluated seroreactivity against cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in relation to testicular-cancer risk in a case-control study, nested within a cohort of prospectively collected serum specimens from 293,692 individuals. For each of 81 cases of testicular cancer identified, 3 controls were randomly selected from the cohort. Serum IgG antibody titers against CMV and EBV were determined using enzyme-linked immunosorbent assays (ELI-SAs) and immunofluorescence methods. Odds ratios (OR) were obtained from conditional logistic-regression models. No association was found between CMV positivity and testicular cancer overall (OR ‫؍‬ 1.08; 95% confidence interval 0.60-1.94); risk for testicular seminoma was increased among CMV seropositive [OR ‫؍‬ 1.70 (0.80-3.59)], whereas seropositivity was associated with decreased risk for testicular nonseminoma [OR ‫؍‬ 0.54 (0.19-1.56)] (p for heterogeneity, 0.09). For EBV, the risk for testicular cancer was increased among individuals seropositive for viral capsid antigen (VCA) [OR ‫؍‬ 2.74 (0.62-12.12)]. The results lend some support to the hypothesis of an infectious etiology, and we propose that future studies should take into account age at infection. Int.

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