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EPR study of radicals generated from bioactive S-nitrosothiols and related thiols

✍ Scribed by Jing Jin; Longmin Wu; Ziyi Zhang

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
156 KB
Volume
40
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

Thermal or photolytic reactions of bioactive S‐nitrosothiols and related thiols in the presence of radical generators in deaerated DMSO or aqueous solutions under argon or saturated with nitric oxide (NO) produced nitroxides and an oxyaminyl radical, which were well characterized by EPR spectra. Nitroxides containing a thiyl substituent were obtained. Possible mechanisms are proposed. Bioactive S‐nitrosothiols such as S‐nitrosoglutathione, S‐nitroso‐N‐acetylpenicillamine and related thiols such as glutathione and N‐acetylpenicillamine were used for the investigation. Radical generators utilized as transient radical sources were 2,2^′^‐azobisisobutyronitrile, 2,2^′^‐azobis(2‐methylpropionamidine) dihydrochloride, tert‐butyl peroxide and benzoyl peroxide. Copyright © 2002 John Wiley & Sons, Ltd.

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