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Eplerenone: A Selective Aldosterone Blocker

✍ Scribed by Stier, Charles T.

Book ID
109106094
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
147 KB
Volume
21
Category
Article
ISSN
0897-5957

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Interconversion pharmacokinetics of eple
Interconversion pharmacokinetics of eplerenone, a selective aldosterone blocker, and its lactone-ring open form
✍ Chyung S. Cook; Liming Zhang πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 118 KB

The interconversion pharmacokinetics of eplerenone and its lactone-ring open form, SC-70303, were examined in dogs using a stable isotope method. [13CD3]EP and SC-70303 were coadministered orally (10 mg/kg) and intravenously (5 mg/kg) as aqueous solutions under fasted conditions. After I.V. administ